As I've mentioned before, I love my Beretta 92FS. It has one big weakness: it's big. Milady can't shoot it comfortably, so we're thinking smaller with her. She likes the Glock 23 some, but I have an irrational problem: I hate striker pistols.
I don't know why, but a pistol is supposed to have a hammer. It doesn't matter if it's the rounded hammer of the 92FS, or the spur design of the SIG P220, if it doesn't have a hammer it just isn't right. I can intellectually justify my problems with Glocks: you cannot double-strike the round in the chamber. Even this isn't terribly rational: most of the time, if you don't go bang, you're either clearing a round or dropping the gun.
I know I'm passing up perfectly good 9mms (Walther P99, Springfield XD, etc.), especially in the "mouse gun" category, but I just can't get past it all. A pistol has a hammer.